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| Web URL(s): | http://dx.doi.org/10.1016/j.bmcl.2006.09.073
Last checked: 02/12/2008
Access conditions: Item is within a limited-access website |
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| Publication Type:
| Report |
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| Author(s): | Pang, Yuan-Ping |
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| Author Affiliation: | Computer-Aided Molecular Design Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota |
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| Title: | Species marker for developing novel and safe pesticides |
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| Source: | Bioorganic & Medicinal Chemistry Letters. Vol. 17, No. 1, January 2007, p. 197-199. |
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| Publishing Information: | Pergamon |
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| # of Pages: | 3 |
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| Keywords: | TIC Keywords: Pesticides; Cholinesterase inhibitors; Schizaphis graminum; Aphids; Hydrolases; Pesticide safety; Pesticide interaction
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| Abstract/Contents: | "Current anticholinesterase pesticides developed during World War II are toxic to mammals because they target a catalytic serine residue of acetylcholinesterases (AChEs) in insects and in mammals. A sequence analysis of AChEs from 68 species and three-dimensional models of the greenbug and English grain aphid AChEs reported herein reveal that a cysteine residue is present at the active sites of greenbug and aphid AChEs but absent at those of mammalian AChEs. This discovery enables the design of novel and safe pesticides that target the cysteine residue rather than the ubiquitous serine residue." |
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| Language: | English |
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| References: | 16 |
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| Note: | Figures |
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| ASA/CSSA/SSSA Citation (Crop Science-Like - may be incomplete):
Pang, Y.-P. 2007. Species marker for developing novel and safe pesticides. Bioorganic & Medicinal Chemistry Letters. 17(1):p. 197-199. |
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| Web URL(s):
http://dx.doi.org/10.1016/j.bmcl.2006.09.073
Last checked: 02/12/2008
Access conditions: Item is within a limited-access website |
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