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| DOI: | 10.1093/jnci/djx233 |
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| Web URL(s): | https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djx233/4590280
Last checked: 03/15/2018
Access conditions: Item is within a limited-access website
https://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djx233/21784930/djx233.pdf
Last checked: 03/15/2018
Access conditions: Item is within a limited-access website |
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| Author(s): | Andreotti, Gabriella;
Koutros, Stella;
Hofmann, Jonathan N.;
Sandler, Dale P.;
Lubin, Jay H.;
Lynch, Charles, F.;
Lerro, Catherine C.;
De Roos, Anneclaire J.;
Parks, Christine G.;
Alavanja, Michael C.;
Silverman, Debra T.;
Freeman, Laura E. Beane |
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| Author Affiliation: | Andreotti, Koutros, Hofmann, Lerro, Silverman, and Freeman: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Lubin: Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Alavanja: Formerly of Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD; Sandler and Parks: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC; Lynch: Department of Epidemiology, University of Iowa, Iowa City, IA and State Health Registry of Iowa, Iowa City, IA; Freeman: Department of Environmental and Occupational Health, Drexel University Dornsife School of Public Health, Philadelphia, PA |
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| Title: | Glyphosate use and cancer incidence in the agricultural health study |
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| Source: | Journal of the National Cancer Institute. Vol. 110, No. 5, 2018, p. 1-8. |
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| Publishing Information: | Washington, D.C.: National Cancer Institute |
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| # of Pages: | 8 |
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| Related Web URL: | https://www.researchgate.net/publication/321082243_Glyphosate_Use_and_Cancer_Incidence_in_the_Agricultural_Health_Study
Last checked: 03/15/2018
Notes: Abstract only |
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| Keywords: | TIC Keywords: Cancer; Carcinogens; Chemical exposure; Chemical toxicity; Glyphosate; Health concerns; Herbicide profile; Lymphatic cancer; Organization profile; Risk assessment
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| Business Name: | Agricultural Health Study |
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| Abstract/Contents: | "Background Glyphosate is the most commonly used herbicide worldwide, with both residential and agricultural uses. In 2015, the International Agency for Research on Cancer classified glyphosate as probably carcinogenic to humans, noting strong mechanistic evidence and positive associations for non-Hodgkin lymphoma (NHL) in some epidemiologic studies. A previous evaluation in the Agricultural Health Study (AHS) with follow-up through 2001 found no statistically significant associations with glyphosate use and cancer at any site. Methods The AHS is a prospective cohort of licensed pesticide applicators from North Carolina and Iowa. Here, we updated the previous evaluation of glyphosate with cancer incidence from registry linkages through 2012 (North Carolina)/2013 (Iowa). Lifetime days and intensity-weighted lifetime days of glyphosate use were based on self-reported information from enrollment (19931997) and follow-up questionnaires (19992005). We estimated incidence rate ratios (RRs) and 95% confidence intervals (CIs) using Poisson regression, controlling for potential confounders, including use of other pesticides. All statistical tests were two-sided. Results Among 54 251 applicators, 44 932 (82.8%) used glyphosate, including 5779 incident cancer cases (79.3% of all cases). In unlagged analyses, glyphosate was not statistically significantly associated with cancer at any site. However, among applicators in the highest exposure quartile, there was an increased risk of acute myeloid leukemia (AML) compared with never users (RR=2.44, 95% CI=0.94 to 6.32, Ptrend = .11), though this association was not statistically significant. Results for AML were similar with a five-year (RRQuartile 4 = 2.32, 95% CI?=?0.98 to 5.51, Ptrend = .07) and 20-year exposure lag (RRTertile 3 = 2.04, 95% CI=1.05 to 3.97, Ptrend = .04). Conclusions In this large, prospective cohort study, no association was apparent between glyphosate and any solid tumors or lymphoid malignancies overall, including NHL and its subtypes. There was some evidence of increased risk of AML among the highest exposed group that requires confirmation." |
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| Language: | English |
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| References: | 32 |
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| Note: | Tables |
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| ASA/CSSA/SSSA Citation (Crop Science-Like - may be incomplete):
Andreotti, G., S. Koutros, J. N. Hofmann, D. P. Sandler, J. H. Lubin, C. F. Lynch, et al. 2018. Glyphosate use and cancer incidence in the agricultural health study. Journal of the National Cancer Institute. 110(5):p. 1-8. |
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| DOI: 10.1093/jnci/djx233 |
| Web URL(s):
https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djx233/4590280
Last checked: 03/15/2018
Access conditions: Item is within a limited-access website
https://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djx233/21784930/djx233.pdf
Last checked: 03/15/2018
Access conditions: Item is within a limited-access website |
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