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| Web URL(s): | http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9063(199610)48:2<135::AID-PS451>3.0.CO;2-J/epdf
Last checked: 10/07/2015
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| Publication Type:
| Refereed |
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| Author(s): | Cohen, Ephraim;
Quistad, Gary B.;
Jefferies, Phillip R.;
Casida, John E. |
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| Author Affiliation: | Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720-3112 USA |
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| Title: | Nimbolide is the principal cytotoxic component of neem-seed insecticide preparations |
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| Source: | Pesticide Science. Vol. 48, No. 2, October 1996, p. 135-140. |
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| Publishing Information: | London : Society of Chemical Industry |
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| # of Pages: | 6 |
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| Keywords: | TIC Keywords: Azadirachtin; Insecticides; Botanical insecticides; Insect growth regulators; Insecticidal action; Azadirachta indica; Toxicity; Nimbolide
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| Abstract/Contents: | "Several neem-seed extracts, some used for preparing commercial azadirachtin-containing insecticides, are cytotoxic to N1E-115 murine neuroblastoma cells with ICâ”â° values of 20-200 ^Dmg extract mlââ culture medium. Bioassay-directed fractionation by reversed-phase HPLC shows that the toxicity to N1E-115 cells is associated primarily with a single minor component identified by isolation and NMR and MS as nimbolide with an IC^D5^D]0 of 1.5 ^Dmg mlââ (3.2 ^DmM). The difference in quantity of nimbolide in seven neem extract sources generally correlates with their overall cytotoxicity. Three other limonoids (epoxyazadiradione, salnnin and possibly deacetylsalannin) but not azadirachtin, nimbin and deacetylnimbin contribute in small part to the cytotoxicity. Reconstituted neem extract with only nimbolide removed is less cytotoxic than the original extract. It therefore appears that nimbolide is the principal cytotoxic component of the neem extracts examined and that such minor constituents may warrant consideration in safety evaluations." |
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| Language: | English |
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| References: | 21 |
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| Note: | Figures
Tables |
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| ASA/CSSA/SSSA Citation (Crop Science-Like - may be incomplete):
Cohen, E., G. B. Quistad, P. R. Jefferies, and J. E. Casida. 1996. Nimbolide is the principal cytotoxic component of neem-seed insecticide preparations. Pest Manage. Sci. 48(2):p. 135-140. |
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| Web URL(s):
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9063(199610)48:2<135::AID-PS451>3.0.CO;2-J/epdf
Last checked: 10/07/2015
Requires: PDF Reader
Access conditions: Item is within a limited-access website |
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MSU catalog number: SB 951 .A1 P45 |
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