Full TGIF Record # 85398
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Web URL(s):https://link.springer.com/article/10.1007/BF00194137
    Last checked: 05/15/2017
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Publication Type:
i
Report
Author(s):Nakagawa, Y.; Yaguchi, K.; Suzuki, T.
Author Affiliation:Nakagawa: Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Hyakunin-cho, Shinjuku-ku, Tokyo, Japan; and Yaguchi and Suzuki: Tama Branch Laboratory, Tokyo Metropolitan Research Laboratory of Public Health, Hyakunin-cho, Shinjuku-ku, Tokyo, Japan
Title:Comparative cytotoxicity between butylated hydroxytoluene and its methylcarbamate derivative, Terbucarb, on isolated rat hepatocytes
Source:Bulletin of Environmental Contamination and Toxicology. Vol. 52, No. 4, April 1994, p. 511-515.
Publishing Information:New York: Springer-Verlag New York
# of Pages:5
Keywords:TIC Keywords: Antioxidants; Comparisons; Terbucarb; Toxicological assessment
Abstract/Contents:"Butylated hydroxytoluene (3,5-di-tert-butyl-4-hydroxytoluene; BHT) is widely used as phenolic antioxidant in processed foods, cosmetics and petroleum products. It is well known that high doses of BHT cause acute hepatic damage accompanied by centrilobular necrosis in rats (Nakagawa et al. 1984). The hepatic damage is associated with prolonged depletion of glutathione (GSH). Terbucarb (2,6-di-tert-butyl-para-tolyl-methylcarbamate), which has a methylcarbamate group substituted for the phenol group on BHT, was developed as an insecticide and is also presently used as a herbicide on turfgrass (Jagschitz 1973). Despite the metabolic and toxicological details known about BHT in vivo (WHO Technical Report Series 1987) and in vitro (Nakagawa and Tayama 1988), no extensive studies have been reported on the metabolism and toxicity of Terbucarb. The isolated hepatocyte system provides a very useful system for the study of the temporal sequences leading to cell damage caused by chemicals and drugs. Here, using freshly isolated rat hepatocytes, we report on the comparative toxic effects of BHT and its methylcarbamate derivative, Terbucarb."
Language:English
References:17
Note:Figures
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ASA/CSSA/SSSA Citation (Crop Science-Like - may be incomplete):
Nakagawa, Y., K. Yaguchi, and T. Suzuki. 1994. Comparative cytotoxicity between butylated hydroxytoluene and its methylcarbamate derivative, Terbucarb, on isolated rat hepatocytes. Bull. Environ. Contam. Toxicol. 52(4):p. 511-515.
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Web URL(s):
https://link.springer.com/article/10.1007/BF00194137
    Last checked: 05/15/2017
    Requires: PDF Reader
    Access conditions: Item is within a limited-access website
    Notes: Guide page
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